Growth and Remodelling of Intracranial Saccular AneurysmsA. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly understood. We propose a model based on three competing remodeling mechanisms - one passive and two active. Despite drastic simplifying assumptions, preliminary numerical experiments attest to the potential of our model to account for nontrivial evolutions ensuing from accidental perturbations of a homeostatic state.
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