Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Analysis Of Particle Trajectories For Magnetic Drug Targeting

A. Heidsieck, and B. Gleich
Zentralinstitut für Medizintechnik, TU München, München, Germany

The technique of magnetic drug targeting binds genetic material or drugs to superparamagnetic nanoparticles and accumulates them via an external magnetic field in a target region. However, it is still a challenge for this approach to succeed in areas with high flow rates, like the aorta or the heart ventricle. The magnetic field sources have to be accurately optimized and adapted to the local ...

From CT Scan to Plantar Pressure Map Distribution of a 3D Anatomic Human Foot

S. Gerbino, and P. Franciosa
University of Molise, School of Engineering, Via Duca degli Abruzzi, Termoli, Italy

Understanding the stress-strain behavior of human foot tissues and pressure map distributions at the plantar interface is of interest into biomechanical investigations. In particular, monitoring plantar pressure maps is crucial to establishing the perceived human comfort of shoe insoles. A 3D anatomical detailed FE human foot model was created, starting from CT (Computer Tomography) scans of a ...

Understanding the Role of Nanomaterials in DNA Biosensors Through Finite Element Analysis

J. C. Kumaradas[1], A. Zhang[2], Y. D. Davletshin[1]
[1]Ryerson University, Toronto, ON, Canada
[2]University of Waterloo, Waterloo, ON, Canada

Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...

Rapid Prototyping of Biosensing Surface Plasmon Resonance Devices using COMSOL & Matlab software

J.J. Dubowski[1], and D.Carrier[1]
[1]Department of Electrical and Computer Engineering, Université de Sherbrooke, Quebec, Canada

We present a Finite Element Method simulation procedure that allows rapid development of prototype devices comprising novel self-referenced interference SPR (surface plasmon resonance) biosensing microstructures. The procedure takes advantage of  COMSOL Multiphysics and MATLAB software and their bi-directional link. The simulation is made using COMSOL RF Module, 2D harmonic propagation ...

3D Modeling of Impedance Spectroscopy for Protein Detection in Nanoneedle Biosensors

H. Esfandyarpour1,2, A. Maiyegun1, and R. W. Davis2
1Center for Integrated Systems, Department of Electrical Engineering, Stanford University, Stanford, CA, USA
2Stanford Genome Technology Center, Stanford, CA, USA

We present a preliminary investigation of a Nanoneedle biosensor as an ultra sensitive and localized impedance biosensor using COMSOL.This preliminary study was performed to prove the feasibility of the impedance biosensor for detection of protein or nucleic acids. By monitoring the change in capacitance and impedance of this structure, we aim to characterize and classify biological species such ...

Numerical Investigation of a Time-dependent Magnetic Actuation Technique for Tagging Biomolecules with Magnetic Nanoparticles in a Microfluidic System

A. Munir, J. Wang, Z. Zhu, and H.S. Zhou
Worcester Polytechnic Institute, Worcester, MA, USA

The magnetic body forces that act on mono-dispersed magnetic nanoparticles (MNPs) tagged biomolecules in a microfluidic system can be efficiently used in various applications that involve separation and detection including DNA and protein analysis, bio-defense, drug delivery, and pharmaceutical development. In this work, we report an FEM model to demonstrate a novel method of tagging biomolecules ...

Polymer Compositional Profile Controls By-Product Fate from Erodible Endovascular Scaffolds

T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Columbia, SC

Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues. We developed an integrated computational model of polymeric scaffold degradation, by-product ...

Studies of Lead Free Piezo-Electric Materials Based Ultrasonic MEMS Model for Bio sensor

P. Pattanaik[1], S. K. Kamilla[1], D. P. Das[2], S. K. Pradhan[3]
[1]MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
[2]Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
[3]Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India

This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...

Determination of Mechanic Resistance of Osseous Element Through Finite Element Modeling

E. Isaza[1], E. Salazar[1], L. Florez[1]
[1]Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

The consequences of hip fracture and femoral fracture are widely known. The mechanical strength of the femur varies in every person, but it is possible to predict the mechanical resistance with parameters like density, dimensions and mineral content. This paper uses different models and empirical studies to determine the mechanical properties of the human femur, developing isotropic and ...

Design and Simulation of a Microscale Magnetophoretic Device for the Separation of Nucleated Fetal Red Blood Cells from Maternal Blood

G. Schiavone[1], D.M. Kavanagh[2], and M.P.Y Desmulliez[2]

[1]Politecnico di Torino, Torino, Italy
[2]MIcroSystems Engineering Centre, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, United Kingdom

Intense research has been carried out into methods that aim at harvesting fetal cells from maternal blood as substitutes to amniocentesis and chorionic villus sampling. This work focuses on the separation of fetal nucleated red blood cells from the maternal circulation based on their intrinsic magnetic properties. The design and simulation of a magnetophoretic separator is described, as it will ...

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